Dosing of Neuromuscular Blocking Agents Should Be Done by Reliable Neuromuscular Monitoring and Factors Influencing the Dosing

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...

tracheal intubation without the use of neuromuscular blocking agents

Histamine release by neuromuscular blocking agents.

Histamine release by neuromuscular blocking agents Sir,—The design of the study by Naguib and colleagues [1] on the histamine releasing potencies of various neuromuscular blocking drugs resulted in cardiovascular changes which were profound, adverse and predictable. For example, the data sheet for mivacurium suggests administration over 5–15 s. The authors chose 5 s, despite quoting references ...

Indications for Neuromuscular Blocking Agents

©International Anesthesia Research Society. Unauthorized Use Prohibited. Almost thirty years ago, residual neuromuscular blockade was documented in a surprisingly high proportion of patients (30%), despite an almost systematic use of anticholinesterase agents.1 Since then, even with the development of shorter-acting neuromuscular blockers, pharmacological reversal, and more widespread use of ne...

Neuromuscular blocking agents: a review.

The author provides a review of the mechanism of neuromuscular transnission, as well as the Nechanisn of action and differences between curare and succinylcholine. Effects of these two relaxants on various organs and tissues are discussed, as are their onset of action, duration, elimination, and clinical uses. In order to understand how skeletal muscle re-laxants act, the mechanism of neuromusc...